Antitubercular Studies. I

Studies on Thiazolyliminothiazoline Derivatives as Potential Antitubercular Agents

In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2ylidenamino]thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio)thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was filtered and recrystallized from ethanol. The chemical structures of the synthesized compounds were proven by elemental analysis, IR, 1H-NMR and MS spectral data. The compounds wer...

Studies on the Antitubercular Compounds (XII) Effect on Antitubercular Activity of Acid Hydrazide by the Condensation with Aldehyde Shichiro

Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies

In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (4a-i, 5a-f, and 6a-c) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e, and ...

Studies I N Carcinogenesis

Since 1915, when Yamagiwa and Ichikawa succeeded in producing tar cancer experimentally, considerable progress has been made towards the elucidation of the chemical nature of substances capable of inciting malignant changes in cells. Outstanding contributions since then have been those of Bloch and Dreifuss (192 1) and of Kennaway and his colleagues. From the work of Bloch and Ilreifuss it appe...

Antitubercular inhaled therapy: opportunities, progress and challenges.

Pulmonary tuberculosis remains the commonest form of this disease and the development of methods for delivering antitubercular drugs directly to the lungs via the respiratory route is a rational therapeutic goal. The obvious advantages of inhaled therapy include direct drug delivery to the diseased organ, targeting to alveolar macrophages harbouring the mycobacteria, reduced risk of systemic to...